Prolonged Sitting Tied to Brain Atrophy

Prolonged periods of sitting in middle age is tied to brain atrophy, new research shows.

Using MRI, investigators found sedentary behavior is a significant predictor of medial temporal lobe (MTL) thinning and its substructures and that physical activity, even at high levels, does not offset the harmful effects of sitting for extended periods.

Merger to Establish Big Hospital Chain

Two large hospital systems in the Midwest and mid-Atlantic said they plan to merge, in another example of hospitals bulking up as the battle for patients becomes fierce.
 A combination of Bon Secours Health System Inc., a nonprofit based in Marriott sville, Md., and Mercy Health, a nonprofit in Cincinnati, would rank as one of the largest chains nationwide, with 43 hospitals and operations in seven states.
 The combination would add to a string of health-care deals that aim to create behemoths with more sway.

Profits Are Hidden in the Prescription Drug Supply Chain

Depending on how you look at them, pharmacy-benefit managers are either low margin middlemen that fight to reduce drug costs or highly profitable intermediaries that earn more when drug prices rise.
 Pharmacy-benefit managers are hired by businesses such as insurers that pay for drugs to negotiate lower prices with pharmaceutical companies. When Express Scripts Holding reports fourth-quarter earnings on Tuesday, analysts expect a margin of just 4.7%, according to FactSet. Rival companies owned by CVS Health and UnitedHealth Group report similarly low margins.

Doctors Use Poetry to Recharge

WHAT IS A good gift for a freshly minted physician? In Scotland, it is a book of poetry. Each year, the 900 or so graduating medical students in Scotland receive a free copy of a poetry book titled “Tools of the Trade: Poems for New Doctors.” It's a pocket-size book with fewer than 100 pages, so doctors can easily carry it while on duty. The poems are grouped into five themes designed to help young physicians: looking after yourself, looking after others, beginnings, being with illness, and endings.

Digital Pill Wins FDA's Approval

U.S. authorities approved the world's first digital drug, an antipsychotic pill that signals smartphones once it reaches the gut so doctors can track whether patients are taking their medication.
 Tuesday's greenlight from the Food and Drug Administration means Japan's Otsuka Pharmaceutical Co. can implant a chip containing minerals like silicon, magnesium and copper inside tablets of Abilify, which is widely used to treat schizophrenia, bipolar disorder and other mental illnesses.

Biotech's Breakthrough Year

Pay attention only to politics and you might think 2017 was a parade of horribles, yet most Americans saw their living standards rise and business innovations are happening apace. Consider the lifesaving medical breakthroughs greenlighted this year by the Food and Drug Administration.

CVS Sets Next-Day Delivery Of Drugs

CVS Health Corp. is launching next-day delivery of prescription medication, a move that comes as the drugstore giant faces declining retail sales and potential competition from Inc.
 CVS on Monday said it would offer the service nationwide starting early next year, and same-day delivery in some urban areas. In Manhattan, the company will offer free same day delivery service starting Dec. 4.

Cardinal Health CEO to Step Down

Cardinal Health Inc. said Monday that Chief Executive George Barrett will step down in January after more than eight years in the post, as pricing pressure for generic drugs has weighed on the company in recent months.
 Mr. Barrett, 62 years old, will remain in his role as executive chairman until the company's shareholder meeting in November 2018.

Immunotherapy Treatments for Cancer Gain Momentum

The science of using immunotherapy to treat cancer is advancing rapidly, marked by the National Cancer Institute's recent disclosure that a metastatic breast-cancer patient is now cancer-free, regulators' expected approval of a major lymphoma treatment this fall, and the unveiling Thursday of a partnership between government researchers and drug makers.